What is Food Intolerance

Countless numbers of people suffer from food sensitivity and intolerance - often without being aware of it. Effects can range from common digestive system problems including abdominal pain and spasms, diarrhea, constipation, and flatulence, to headaches, to skin rash and eczema - all due to the body's inability to thoroughly digest food caused by the lack of proper amounts of certain enzymes.

Many food intolerances are confused with food allergies and are caused by elevated levels of histamine in food. These elevated histamine levels can make eating foods, such as pizza, fish, wine, beer, and many other foods a miserable experience. Until now, one of the only options was to avoid these histamine-containing foods.

Histame is the first product worldwide that decreases histamine levels that cause food intolerance by replenishing the body's digestive enzyme Diamine Oxidase (DAO).* This clinically shown dietary supplement regulates histamine levels in the body, unlike antihistamines, which only block the histamine.*

Food intolerance versus food allergy

It is important to recognize the difference between food intolerance and food allergy. Non-allergenic histamine food intolerance is mostly brought on by foods not processed properly in the intestinal tract.

Food intolerance is a digestive system response to the inability to digest particular ingredients in food that does not involve the immune system. In contrast, a food allergy is an abnormal response to food triggered by the body’s immune system.

Reactions to histamine found in foods are not food allergies, though the symptoms can look and feel the same. Furthermore, the severity of the food intolerance symptoms is dependent on the ingested amounts of histamine-rich food.

IMPORTANT: Allergic reactions can cause serious illness and, in some cases, death. If you have a food allergy, it is extremely important that you work with your health care provider to find out what food(s) cause your allergic reactions.


A biogenic component often found is processed foods, histamine is an amine (nitrogen) derived from the decarboxylation of the amino acid histidine. In the digestive tract (GI), Diamine Oxidase (DAO) breaks down histamine.* Histamine can mimic the discomforts commonly caused by immune system-based food allergies.

Other common types of food intolerance

  • * Food poisoning
  • * Lactose intolerance
  • * Gluten and nut intolerance
  • * Carbohydrate intolerance
  • PBS Investigates Food Intolerance
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